Our Research
Design → Engineer → Deliver
A Multi-Scale Research Approach
Our research group focuses on the fundamental understanding and engineering of protein-material interfaces to develop next-generation therapeutic delivery systems. By combining computational tools, chemical biology, and advanced materials science, we create protein therapeutics that are fundamentally more intelligent and controllable than conventional approaches.
From Design to Delivery
Precision Protein Design
How can we predict and control exactly where modifications occur on proteins?
The foundation of controllable therapeutics begins with molecular-level precision. We use computational methods to predict and precisely control protein modification sites, enabling the rational design of protein therapeutics with pre-determined properties. Our approach combines molecular dynamics simulations with experimental validation to create predictive models that guide site-specific bioconjugation strategies. Using structure-guided design principles, we can target specific amino acid residues with atomic-level accuracy. This foundational capability allows us to engineer proteins with atomic level precision, setting the stage for creating responsive systems and advanced delivery platforms
- PRELYM algorithm for lysine reactivity prediction
- Structure-guided modification site selection
- Controlled polymer density and location
- Predictable therapeutic proteins
Smart Protein Engineering
Can we create proteins that intelligently adapt to their environment?
Building on our precision design capabilities, we engineer smart protein systems that intelligently respond to specific biological stimuli such as pH, temperature, or chemical environment. These responsive systems enable proteins to function optimally under diverse conditions while adapting their behaviour based on the local cellular environment. Through rational surfactant selection or polymer engineering, we create adaptive therapeutic systems that can tune their lipophilicity, activity, stability, and substrate specificity in response to environmental changes. These smart, responsive proteins become the foundation for advanced therapeutic formulations that can adapt and deliver targeted treatments precisely when and where needed.
- Stimulus-responsive protein engineering
- Hydrophobic ion-pairing for tailored solubility
- Enhanced stability under non-native conditions
- Controlled activity and specificity modulation
Advanced Therapeutic Formulations
How can we create programmable delivery systems for protein therapeutics?
We design and synthesise novel formulation platforms that integrate our precisely modified and responsive proteins into complete therapeutic delivery systems. These platforms overcome biological barriers and provide programmable control over when, where, and how therapeutic proteins are delivered. Our approach encompasses innovative protein-based carriers (e.g., pH-responsive ferritin nanocages) and advanced lipid-based systems for oral delivery, all engineered for controlled therapeutic action. These therapeutic platforms combine predictable design, responsive behaviour, and controlled delivery to create next-generation protein medicines with programmable therapeutic action.
- Self-assembling protein nanocages for controlled encapsulation
- Lipid-based nanocarriers for oral biotherapeutic delivery
- Site-specific targeting through engineered carriers
- Stimuli-triggered release mechanisms